Trace Elements in Medicine (Moscow)
2019, 20(4): 51-56
ORIGINAL PAPERS

BIOELEMENTAL COMPOSITION OF ORGANS OF EXPERIMENTAL ANIMALS BY FUROSEMIDE LOADING

N.N. Chuchkova¹, O.M. Kanunnikova², M.V. Smetanina¹

¹ Izhevsk state medical Academy, Kommunarov str., 281, Izhevsk, 426034, Russia
² Udmurt Federal Center, Ural branch, Russian Academy of Sciences «Scientific Center of Metallurgy Physics and Materials Science», Tatiana Baramzina str., 34, Izhevsk, 426067, Russia

DOI: 10.19112/2413-6174-2019-20-4-51-56 

ABSTRACT. The administration of furosemide to experimental animals at a dose of 30 mg / kg of body weight for 10 days leads to hypomagnesemia (the amount of magnesium is reduced by 1.65 times), hyperphosphatemia (the amount of phosphorus is increased by 54.6%), a change in the ratio of elements (calcium/magnesium in the control is ~ 2:1, with furosemide load – 3:1, calcium/phosphorus changes from 2:1 – in the control to 1:1 – in the experiment). The most significant quantitative changes are two macroelements – magnesium and calcium, and two trace elements – zinc and iron. Changes in the elemental composition are least pronounced in the blood serum. Furosemide load is accompanied by diselementosis of organs. Hypomagnesaemia is accompanied by hyper-magnesium in tissues, manifested in varying degrees, most pronounced in the organs of immunogenesis (thymus and spleen). In the myocardium the calcium content increases significantly (84.5%), which leads to a change in the ratio of Ca/Mg c 1:3 (control) to 1:6 (furosemide administration). In the tissue of the heart and kidneys with furosemide load appears not determined in the normal manganese, liver is characterized by a tenfold increase in the amount of zinc. In the spleen mass concentration phosphorus (39.5%) reduced significantly, levels calcium (52.8%) and potassium (79.5%) increased, in the thymus –amount of calcium (64.8%) and iron (26.3%) increased.

KEYWORDS: furosemide, elemental composition of organs.